Evidence for a Role of Nav 1 . 6 in Facilitating Increases in Neuronal Hyper - excitability During 2 Epileptogenesis

Title Page 1 Evidence for a Role of Nav1.6 in Facilitating Increases in Neuronal Hyper-excitability During 2 Epileptogenesis. 3 4 Nicholas J. Hargus, Aradhya Nigam, Edward H. Bertram III, Manoj K. Patel 5 Departments of Anesthesiology and Neurology, Neuroscience Graduate Program University of 6 Virginia Health System, Charlottesville VA 22908. 7 8 Author Contribution: NJH, AN and MKP performed the experiments. NJH, EHB and MKP designed 9 the experiments. NJH and MKP wrote the manuscript. 10 11 Running Head: Alterations in Nav1.6 during epileptogenesis. 12 13 Corresponding Author#: Manoj K. Patel, Department of Anesthesiology, Box 800710, University of 14 Virginia Health System, Charlottesville VA, 22908-0710, USA. Tel: +1 434 924 9693, Fax: +1 434 924 15 2105,(email [email protected]). 16 17 Articles in PresS. J Neurophysiol (June 5, 2013). doi:10.1152/jn.00383.2013